The US envoy to the United Nations, Nikki Haley, has accused the UN of damaging the prospects for peace between Israel and the Palestinians.
The organization “has outrageously been one of the world’s foremost centers of hostility towards Israel”, she said.
Haley was addressing a meeting of the Security Council called after Trump’s decision to relocate the US embassy to Jerusalem.
The move has been widely condemned and sparked clashes in the West Bank.
Israel has carried out air strikes against targets in the Gaza Strip, injuring a number of people, after Palestinian militants fired rockets into Israeli territory.
Two Palestinian men died after Israeli troops fired on crowds in Gaza.